In Vitro TNF- Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model

Figure 2

Treatments with the aqueous (SAA) and organic (SAO) fractions of Stryphnodendron adstringens reduce total cells and neutrophil recruitment into the knee joint during LPS-induced arthritis. The total number of cells (a) and numbers of neutrophils in the synovial cavity (b) were assessed 12 h after inflammation induction with LPS (vehicle-, V-, SAA-, and SAO-treated mice groups) or PBS (control: C) into the knee joints of mice. The concentration of CXCL1 (c) was assessed by ELISA 12 h after inflammation induction and expressed as pg/100 mg of tissue. Dexamethasone (Dexa, 4 mg/Kg) was used as control. All results are expressed as mean ± standard error of mean (SEM) and are representative of at least two experiments. when compared to vehicle-treated mice () (ANOVA, Student-Newman-Keuls posttest).

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