Research Article

The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice

Figure 3

(a) (A) NF-κB p65, cyclin D1, and p16 expression in tumors after treatment of BALB/C mice with 5-Fu, SLPE, or 5-Fu and SLPE by western blotting analysis. 1–3, control group; 4–6, 5-Fu at 25 mg/kg; 7–9, SLPE at 0.1 mg/kg; 10–12, SLPE and 5-Fu. (B)–(D) Data are presented as means ± SD for 12 tumor specimens in each group (, ). (b) Hematoxylin and eosin staining of gastric tumors after 1 day of treatment with 5-Fu, SLPE, or 5-Fu and SLPE (magnification, 400x). Necrosis was not detected in tumors from control mice (G1; magnification, 400x) and in tumors treated with SLPE (G3; magnification, 200x). (G2) Necrosis was detected in tumors from mice treated with 5-Fu (G2; magnification, 400x) or 5-Fu and SLPE (G4; magnification, ×200).