Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus
The effect of maoto was observed in the very early phase of influenza virus infection. A549 cells infected with PR8 (moi = 1) were cultured for 6 hr. The length of maoto treatment was varied in each experiment. Levels of mRNA for NS and PA segment of PR8 were assayed by real-time PCR analysis. (a) Cells were treated with maoto for 6 hr. Open and closed circles indicate control and maoto, respectively. (b) Maoto treatment for 0–2, 2–4, or 4–6 hr. (c) Maoto treatment for 0–30, 30–60, 60–90, or 90–120 min. versus medium only.
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