Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo

Figure 4

Real-time PCR analysis of MIFT, TRP-1, and tyrosinase gene expression in B16F10 melanocytes treated with 25 μM isofraxidin, 25 μM compound 1 or IBMX for 48 h. (a) Expression of MIFT. compared to untreated cells; for increased expression compared to isofraxidin treated cells. (b) Expression of TRP-1. compared to untreated cells. (c) Expression of tyrosinase. compared to untreated cells; for increased expression compared to isofraxidin treated cells.

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