Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo

Table 1

¹H and ¹³C NMR spectroscopic data (600 MHz, methanol-d₄) for isofraxidin 7-O-(6′-O-p-coumaroyl)-β-glucopyranoside.

Position	( in Hz)		HMBC
2	—	162.7
3	6.16 1H, d (9.6)	115.7	C-2, 4a
4	7.64 1H, d (9.6)	145.7	C-2, 5
4a	—	116.9
5	6.90 1H, s	105.9	C-4, 6, 7, 8a
6	—	151.8
7	—	143.1
8	—	142.7
8a	—	144.0
1′	5.20 1H, d (7.5)	103.9	C-7
2′	3.55 1H, dd (7.5, 9.0)	75.7	C-1′, 3′,
3′	3.47 1H, t (9.0)	77.9	C-2′, 4′
4′	3.40 (1H, t, 9.0)	72.2	C-3′, 5′
5′	3.50 1H, m	75.9	C-4′
6′	4.39 1H, dd (11.4, 7.2)	64.4	C-4′, 5′
	4.34 1H, dd (11.4, 2.0)
1′′	—	127.1
2′′/6′′	7.32 2H, d (8.7)	131.3	C-4′′
3′′/5′′	6.80 2H, d (8.7)	117.1	C-1′′, 4′′
4′′	—	161.5
7′′	7.37 1H, d (15.9)	146.5	C-1′′, 2′′/6′′, 9′′
8′′	6.10 1H, d (15.9)	114.9	C-7′′, 9′′
9′′	—	168.7
6-OMe	3.88 3H, s	57.2	C-6
8-OMe	3.99 3H, s	62.5	C-8

HMBC correlations for compound 1.