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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 1583031, 8 pages
Research Article

Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats

1Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan
2Department of Nursing, St. Mary’s Medicine Nursing and Management College, Yilan 266, Taiwan
3Department of Nursing, Tzu Chi University of Science and Technology, Hualien 970, Taiwan
4Department of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan
5Department of Pathology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan
6Institute of Molecular Biology, National Chung Hsing University, Taichung 402, Taiwan

Correspondence should be addressed to Yi-Hsiung Tseng; wt.ude.uhcn.nogard@gnesthy and Ru-Ping Lee; wt.ude.uct.smg@hsif

Received 21 April 2017; Revised 4 July 2017; Accepted 13 July 2017; Published 16 August 2017

Academic Editor: Elia Ranzato

Copyright © 2017 Wan-Ting Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The main objective of wound treatments is to restore the functional skin properties and prevent infection. Traditional Chinese medicine provides alternative anti-inflammatory, antimicrobial, and wound healing therapies. Both Angelica dahurica extract (AE) and Rheum officinale extract (RE) possess antimicrobial activity. In this study, AE and RE were applied in wound treatment to investigate their healing effects. Thirty Sprague-Dawley rats with dorsal full-thickness skin excision were divided into normal saline (NS), AE, RE, AE plus RE (ARE), and Biomycin (BM) groups. The treatment and area measurement of wounds were applied daily for 21 days. Wound biopsies and blood samples were obtained for histology examinations and cytokine analysis. Results showed that wound contraction in ARE group was significantly higher than that in NS and BM groups (P < 0.05). Histological analysis showed that more inflammatory cell infiltration, collagen fibers, and myofibroblasts were observed in ARE treated group than those in NS group on days 3–5. In ARE group, plasma IL-6 levels were elevated during days 3–5 (P > 0.05), and plasma TGF-β1 levels were significantly lower than those in the NS group on days 3-4 (P < 0.05). In conclusion, ARE accelerates wound healing during inflammation and proliferation phases.