Erchen Decoction and Linguizhugan Decoction Ameliorate Hepatic Insulin Resistance by Inhibiting IRS-1Ser307 Phosphorylation In Vivo and In Vitro

<div>ECD and LGZGD serum containing on TNF-<i>α</i>, NF-<i>κ</i>B, and IRS-1Ser307 phosphorylation expressions in BRL cells stimulated with palmitate. <svg height="15.5258pt" id="M91" style="vertical-align:-3.833899pt" version="1.1" viewbox="-0.0498162 -11.6919 69.0313 15.5258" width="69.0313pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M698 316L685 357H469L403 562H360L293 357H78L65 316L239 190L172 -15L207 -40L382 87L556 -40L590 -15L524 190L698 316Z"></path><glyph.data ascent="900" descent="-389" horiz-adv-x="739" vert-adv-y="739"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,6.725,-5.741)"><path d="M120 417C85 417 60 392 60 356S85 295 119 295S178 320 178 356S153 417 120 417ZM100 135C73 135 48 117 48 91C48 73 56 65 62 64C96 56 125 33 125 -4C125 -42 97 -68 46 -89L59 -124C123 -105 195 -59 195 22C195 94 137 135 100 135Z" id="g50-60"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="237" vert-adv-y="237"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.882,-5.741)"><path d="M528 54L331 254L528 455V493H492L294 291L96 493H60V455L257 254L60 54V16H96L294 217L492 16H528V54ZM131 255C131 299 62 299 62 255C62 236 77 221 96 221S131 238 131 255ZM329 54C329 98 260 98 260 54C260 35 275 20 294 20S329 37 329 54ZM527 255C527 299 458 299 458 255C458 236 473 221 492 221S527 238 527 255ZM329 455C329 499 260 499 260 455C260 436 275 421 294 421S329 438 329 455Z" id="g185-63"></path><glyph.data ascent="989" descent="-303" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,14.243,-5.741)"><path d="M120 417C85 417 60 392 60 356S85 295 119 295S178 320 178 356S153 417 120 417ZM100 135C73 135 48 117 48 91C48 73 56 65 62 64C96 56 125 33 125 -4C125 -42 97 -68 46 -89L59 -124C123 -105 195 -59 195 22C195 94 137 135 100 135Z" id="g50-60"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="237" vert-adv-y="237"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,16.4,-5.741)"><path d="M397 654L44 301L397 -52L750 301L397 654Z" id="g185-42"></path><glyph.data ascent="989" descent="-303" horiz-adv-x="794" vert-adv-y="794"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,24.192,.966)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,35.875,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,47.138,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,53.378,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,56.342,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,62.582,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus the HFD group.</div>

Evidence-Based Complementary and Alternative Medicine

fig6

Figure 6

Figure 6: Erchen Decoction and Linguizhugan Decoction Ameliorate Hepatic Insulin Resistance by Inhibiting IRS-1Ser307 Phosphorylation In Vivo and In Vitro 

Figure 6 | Erchen Decoction and Linguizhugan Decoction Ameliorate Hepatic Insulin Resistance by Inhibiting IRS-1Ser307 Phosphorylation In Vivo and In Vitro 