Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

Table 1

Sources of lectins with in vitro inhibitory effect on growth of different cancer cells.

Source	Affected cells	Reference
Fungi
Agrocybe aegerita	HeLa (derived from cervical cancer cells), HL-60 (promyelocytic leukemia), SW480 (lymph node metastasis), SGC-7901, BGC-823, and MGC80-3 (gastric cancer)	[9]
Animals
Aristichthys nobilis gills	HeLa	[10]
Bothrops leucurus venom	B16-F10 (murine skin melanoma), HEp-2 (carcinoma), K562 (chronic myelogenous leukemia), NCI-H292 (lung mucoepidermoid carcinoma)	[11, 12]
Macrovipera lebetina venom	MDA-MB-231 (human breast cancer)	[13]
Plants
Abelmoschus esculentus seeds	MCF-7 (breast cancer)	[14]
Amaranthus mantegazzianus seeds	URM-106 (rat osteocarcinoma)	[15]
Artocarpus heterophyllus seeds	NB4 (leukemia)	[16]
Bauhinia forficata seeds	MCF-7	[17]
Clematis montana stem	L929 (murine fibrosarcoma), HepG2 (hepatocellular carcinoma), HeLa, MCF-7	[18]
Dioscorea opposita tubers	CNE-2 (nasopharyngeal carcinoma), MCF-7, HepG2	[19]
Glycine max seeds	U373MG (glioblastoma astrocytoma), HeLa, HEp-2, HepG2, MDA-MB-231	[20]
Lotus corniculatus	THP-1 (leukemia), HOP62 (lung adenocarcinoma)	[21]
Microgramma vacciniifolia rhizome	NCI-H292	[22]
Momordica charantia seeds	EAC (Ehrlich ascites carcinoma)	[23]
Morus alba leaves	HCT-15 (colorectal adenocarcinoma), MCF-7	[9]
Northeast China black beans	HCT116 (colorectal carcinoma)	[24]
Phaseolus vulgaris cv. extra long autumn purple bean seeds	HNE-2, CNE-1, CNE-2 (nasopharyngeal carcinoma), MCF-7, HepG2	[25]
P. vulgaris Chinese pinto bean seeds	HONE-1 (nasopharyngeal carcinoma)	[26]
P. vulgaris cv. blue tiger king seeds	HepG2	[27]
Pisum sativum seeds	EAC cells	[28]
Polygonatum odoratum	A549 (alveolar basal epithelial adenocarcinoma)	[29]