Antidepressant Mechanism Research of Acupuncture: Insights from a Genome-Wide Transcriptome Analysis of Frontal Cortex in Rats with Chronic Restraint Stress

Table 4

Common significant KEGG pathways for DE genes.

Samples	KEGG pathways
	Upregulated	Downregulated
C versus M ∩ F versus M ∩ A versus M	—	OS: Toll-like receptor signaling pathway
F versus M ∩ C versus M	—	—
A versus M ∩ C versus M	M: histidine metabolism; M: beta-alanine; metabolism; M: glycine, serine, and; threonine metabolism; M: porphyrin and; chlorophyll; metabolism	OS: chemokine signaling pathway; EIP: cytokine-cytokine; receptor interaction; EIP: TNF signaling; pathway; HD: rheumatoid arthritis; HD: Staphylococcus aureus infection; HD: pertussis; HD: malaria; OS: cytosolic; DNA-sensing pathway; HD: legionellosis
F versus M ∩ A versus M	—	—