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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 1691568, 12 pages
Research Article

Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients

1Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria
2Laboratoire de Physiologie Animale, Département de Biologie Animale, Faculté des Sciences de la Nature et de la Vie, Université Constantine 1, 25000 Constantine, Algeria
3Clinic of Urology-Nephrology and Kidney Transplant Daksi, Constantine, Algeria
4CNC–Center for Neuroscience and Cellular Biology, UC-Biotech Building, Biocant Park, University of Coimbra, Coimbra, Portugal
5Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia

Correspondence should be addressed to Paulo J. Oliveira;

Received 1 August 2016; Revised 19 November 2016; Accepted 5 December 2016; Published 4 January 2017

Academic Editor: Michael Silbermann

Copyright © 2017 Somia Lassed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Green tea (GT) has been studied for its effects as antioxidant and cancer-preventive agent. Epidemiological studies showed that GT consumption decreases the risk for prostate cancer (PC). To investigate whether erythrocyte oxidative stress (OS) is associated with PC and whether daily consumption of GT improves the oxidative phenotype, we performed a study in a group of Algerian PC patients, preceded by an in vitro study to characterize composition and antioxidant/antiproliferative activities of the GT used. This contained a high content of phenolic and flavonoid compounds, demonstrating in vitro antioxidant activity and significant antiproliferative effect on human prostate cancer PC-3 cell line. Seventy PC patients and 120 age-matched healthy subjects participated in the study, with glutathione (GSH), malondialdehyde (MDA), and catalase activity evaluated before and after GT consumption. The results showed a reduced GSH and catalase activity and a high level of MDA in erythrocytes from PC patients. The consumption of 2-3 cups per day of GT during 6 months significantly increased GSH concentration and catalase activity and decreased MDA concentration. In conclusion, GT significantly decreased OS in Algerian PC patients. Regular consumption of GT for a long period may prevent men from developing PC or at least delay its progression.