Mechanisms of P-Glycoprotein Modulation by Semen Strychni Combined with Radix Paeoniae Alba

Table 2

Effect of RPAE on strychnine transport in MDCK-MDR1 cells (, ).

Groups	(×10^−6 cm/s)	(×10^−6 cm/s)	ER
1 μg/mL SSE	28.33 ± 2.67	39.39 ± 11.75	1.39 ± 4.40
1 μg/mL SSE + 1 μg/mL RPAE	24.49 ± 1.63	30.73 ± 0.64	1.25 ± 0.39
1 μg/mL SSE + 3 μg/mL RPAE	22.29 ± 8.19	37.39 ± 0.95	1.68 ± 0.12
1 μg/mL SSE + 6 μg/mL RPAE		41.92 ± 1.53	2.13 ± 0.67
1 μg/mL SSE + 100 μM verapamil		39.57 ± 1.53	0.90 ± 0.38

with contrast to the SSE 1 μg/mL group; with contrast to groups without verapamil.