Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 1767301, 11 pages
https://doi.org/10.1155/2017/1767301
Research Article

Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis

1Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
2Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
3Yueyang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
4Department of Acupuncture and Moxibustion, Shanghai Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200437, China

Correspondence should be addressed to Jing Li and Huan-gan Wu

Received 4 September 2016; Accepted 27 December 2016; Published 26 January 2017

Academic Editor: Ke Ren

Copyright © 2017 Yan Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Danese and C. Fiocchi, “Ulcerative colitis,” The New England Journal of Medicine, vol. 365, no. 18, pp. 1713–1725, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. A. N. Ananthakrishnan, H. Khalili, G. G. Konijeti et al., “Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease,” Gut, vol. 63, no. 5, pp. 776–784, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. J. A. Eaden, K. R. Abrams, and J. F. Mayberry, “The risk of colorectal cancer in ulcerative colitis: a meta-analysis,” Gut, vol. 48, no. 4, pp. 526–535, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Ma, C. L. Beilman, V. W. Huang et al., “Similar clinical and surgical outcomes achieved with early compared to late anti-TNF induction in mild-to-moderate ulcerative colitis: a retrospective cohort study,” Canadian Journal of Gastroenterology and Hepatology, vol. 2016, Article ID 2079582, 9 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. A. K. L. Leung and P. A. Sharp, “MicroRNA functions in stress responses,” Molecular Cell, vol. 40, no. 2, pp. 205–215, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. T. Mendell and E. N. Olson, “MicroRNAs in stress signaling and human disease,” Cell, vol. 148, no. 6, pp. 1172–1187, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Caserta, F. Kern, J. Cohen, S. Drage, S. F. Newbury, and M. J. Llewelyn, “Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS),” Scientific Reports, vol. 6, Article ID 28006, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Hatziapostolou, C. Polytarchou, E. Aggelidou et al., “An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis,” Cell, vol. 147, no. 6, pp. 1233–1247, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. C. G. Chapman and J. Pekow, “The emerging role of miRNAs in inflammatory bowel disease: a review,” Therapeutic Advances in Gastroenterology, vol. 8, no. 1, pp. 4–22, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Coskun, J. T. Bjerrum, J. B. Seidelin, J. T. Troelsen, J. Olsen, and O. H. Nielsen, “miR-20b, miR-98, miR-125b-1, and let-7e as new potential diagnostic biomarkers in ulcerative colitis,” World Journal of Gastroenterology, vol. 19, no. 27, pp. 4289–4299, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Wu, N. J. Guo, H. Tian et al., “Peripheral blood MicroRNAs distinguish active ulcerative colitis and Crohn's disease,” Inflammatory Bowel Diseases, vol. 17, no. 1, pp. 241–250, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Wu, S. Zhang, T. Dassopoulos et al., “Identification of microRNAs associated with ileal and colonic Crohn's disease,” Inflammatory Bowel Diseases, vol. 16, no. 10, pp. 1729–1738, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Yang, Y. Ma, C. Shi et al., “Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB,” Biochemical & Biophysical Research Communications, vol. 434, no. 4, pp. 746–752, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Lin, N. C. Welker, Z. Zhao et al., “Novel specific microRNA biomarkers in idiopathic inflammatory bowel disease unrelated to disease activity,” Modern Pathology, vol. 27, no. 4, pp. 602–608, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Calderón-Gómez, H. Bassolas-Molina, R. Mora-Buch et al., “Commensal-specific CD4+ cells from patients with crohn’s disease have a T-helper 17 inflammatory profile,” Gastroenterology, vol. 151, no. 3, pp. 489.e3–500.e3, 2016. View at Publisher · View at Google Scholar
  16. S. Joos, N. Wildau, R. Kohnen et al., “Acupuncture and moxibustion in the treatment of ulcerative colitis: A Randomized Controlled Study,” Scandinavian journal of gastroenterology, vol. 41, no. 9, pp. 1056–1063, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. E.-H. Zhou, H.-R. Liu, H.-G. Wu et al., “Down-regulation of protein and mRNA expression of IL-8 and ICAM-1 in colon tissue of ulcerative colitis patients by partition-herb moxibustion,” Digestive Diseases & Sciences, vol. 54, no. 10, pp. 2198–2206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. H. G. Wu, G. Q. An, H. R. Liu et al., “Clinical study on the prevention and treatment of intestinal fibrosis in ulcerative colitis by moxibustion,” Journal of Acupuncture & Tuina Science, vol. 1, no. 2, pp. 14–17, 2003. View at Google Scholar
  19. H. G. Wu, L. B. Zhou, D. R. Shi et al., “Morphological study on colonic pathology ulcerative colitis treated by moxibustion,” World Journal of Gastroenterology, vol. 6, no. 6, pp. 861–865, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. J. D. Butzner, R. Parmar, C. J. Bell, and V. Dalal, “Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat,” Gut, vol. 38, no. 4, pp. 568–573, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. C. C. M. Gonçalves, L. Hernandes, C. A. Bersani-Amado, S. L. Franco, J. F. D. S. Silva, and M. R. M. Natali, “Use of propolis hydroalcoholic extract to treat colitis experimentally induced in rats by 2,4,6-trinitrobenzenesulfonic acid,” Evidence-based Complementary and Alternative Medicine, vol. 2013, Article ID 853976, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Vilaseca, A. Salas, F. Guarner, R. Rodríguez, M. Martínez, and J. R. Malagelada, “Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis,” Gut, vol. 31, no. 5, pp. 539–544, 1990. View at Publisher · View at Google Scholar · View at Scopus
  23. N. T. Ventham, N. A. Kennedy, E. R. Nimmo, and J. Satsangi, “Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics,” Gastroenterology, vol. 145, no. 2, pp. 293–308, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. H. G. Wu, W. L. Tan, H. P. Chen, Z. Shi, and X. Hua, “Effect of moxibustion on ulcerative colitis and expression of HLA-DR antigen on epithelial cell of the colon,” Acupunct Research, vol. 24, no. 1, pp. 12–16, 1999. View at Google Scholar
  25. H.-R. Liu, L.-Y. Tan, H.-G. Wu et al., “Effect of moxibustion on the synthesis and secretion of collagen by colonic fibroblasts in ulcerative colitis fibrosis rats,” Journal of Acupuncture & Tuina Science, vol. 6, no. 1, pp. 4–7, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. H.-G. Wu, L.-B. Zhou, Y.-Y. Pan et al., “Study of the mechanisms of acupuncture and moxibustion treatment for ulcerative colitis rats in view of the gene expression of cytokines,” World Journal of Gastroenterology, vol. 5, no. 6, pp. 515–517, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. H.-G. Wu, X. Gong, L.-Q. Yao et al., “Mechanisms of acupuncture and moxibustion in regulation of epithelial cell apoptosis in rat ulcerative colitis,” World Journal of Gastroenterology, vol. 10, no. 5, pp. 682–688, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. H.-R. Liu, C. Zhao, Y. Shi, and Y.-J. Gong, “Regulative effects of herbs-partition moxibustion on neutrophil apoptosis in rats with ulcerative colitis,” Chinese Journal of Clinical Rehabilitation, vol. 9, no. 23, pp. 236–238, 2005. View at Google Scholar
  29. H.-G. Wu, H.-R. Liu, L.-Y. Tan et al., “Electroacupuncture and moxibustion promote neutrophil apoptosis and improve ulcerative colitis in rats,” Digestive Diseases & Sciences, vol. 52, no. 2, pp. 379–384, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. Y.-H. Cui, S. Zhou, H.-G. Wu, X.-M. Wang, L.-Y. Tan, and H.-R. Liu, “Regulatory effect of herbs-partition moxibustion on cycloxygenase and prostaglandin E2 in ulcerative colitis rats at apoptosis directions,” Journal of Clinical Rehabilitative Tissue Engineering Research, vol. 12, no. 24, pp. 4680–4684, 2008. View at Google Scholar · View at Scopus
  31. X.-M. Wang, Y. Lu, L.-Y. Wu et al., “Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis,” World Journal of Gastroenterology, vol. 18, no. 46, pp. 6819–6828, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. X.-M. Feng, T.-B. Cheng, H.-G. Wu, H.-R. Liu, and S. Zhou, “Regulation of moxibustion on the expression of NF-κBp65 and PPARγ mRNA in colon of rats with ulcerative colitis,” Journal of Acupuncture & Tuina Science, vol. 12, no. 5, pp. 265–272, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Wu, M. Zikusoka, A. Trindade et al., “MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2α,” Gastroenterology, vol. 135, no. 5, pp. 1624.e24–1635.e24, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. L. B. McKenna, J. Schug, A. Vourekas et al., “MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function,” Gastroenterology, vol. 139, no. 5, pp. 1654–1664.e1, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Koukos, C. Polytarchou, J. L. Kaplan et al., “MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis,” Gastroenterology, vol. 145, no. 4, pp. 842.e2–852.e2, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. W. X. Chen, L. H. Ren, and R. H. Shi, “Implication of miRNAs for inflammatory bowel disease treatment: systematic review,” World Journal of Gastrointestinal Pathophysiology, vol. 5, no. 2, pp. 63–70, 2014. View at Publisher · View at Google Scholar
  37. M. Fasseu, X. Tréton, C. Guichard et al., “Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease,” PLoS ONE, vol. 5, no. 10, article e13160, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Feng, X. Chen, Y. Yu et al., “MiR-126 functions as a tumour suppressor in human gastric cancer,” Cancer Letters, vol. 298, no. 1, pp. 50–63, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. X. Feng, H. Wang, S. Ye et al., “Up-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor IκBα,” PLoS ONE, vol. 7, no. 12, Article ID e52782, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Polytarchou, D. W. Hommes, T. Palumbo et al., “MicroRNA214 is associated with progression of ulcerative colitis, and inhibition reduces development of colitis and colitis-associated cancer in mice,” Gastroenterology, vol. 149, no. 4, Article ID 59828, pp. 981–992, 2015. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Song, Y. Wang, Y. Xi et al., “Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells,” Oncogene, vol. 28, no. 46, pp. 4065–4074, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. S. S. Chavan and K. J. Tracey, “Regulating innate immunity with dopamine and electroacupuncture,” Nature Medicine, vol. 20, no. 3, pp. 239–241, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. H.-D. Lim, M.-H. Kim, C.-Y. Lee, and U. Namgung, “Anti-inflammatory effects of acupuncture stimulation via the vagus nerve,” PLoS ONE, vol. 11, no. 3, Article ID e0151882, 2016. View at Publisher · View at Google Scholar · View at Scopus
  44. T.-M. Ma, N. Xu, X.-D. Ma, Z.-H. Bai, X. Tao, and H.-C. Yan, “Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats,” World Journal of Gastroenterology, vol. 22, no. 8, pp. 2566–2575, 2016. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Han, T.-M. Ma, M.-L. Lu, L. Ren, X.-D. Ma, and Z.-H. Bai, “Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis,” World Journal of Gastroenterology, vol. 20, no. 32, pp. 11297–11304, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. T. Derrick, A. R. Last, S. E. Burr et al., “Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection,” BMC Infectious Diseases, vol. 16, no. 1, pp. 1–11, 2016. View at Publisher · View at Google Scholar · View at Scopus
  47. G. Fan, X. Jiang, X. Wu et al., “Anti-inflammatory activity of tanshinone IIA in LPS-stimulated RAW264.7 macrophages via miRNAs and TLR4–NF-κB pathway,” Inflammation, vol. 39, no. 1, pp. 375–384, 2016. View at Publisher · View at Google Scholar · View at Scopus
  48. L. Emdad, A. Janjic, M. A. Alzubi et al., “Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness,” Neuro-Oncology, vol. 17, no. 3, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  49. G. Lan, L. Yang, X. Xie, L. Peng, and Y. Wang, “MicroRNA-490-5p is a novel tumor suppressor targeting c-FOS in human bladder cancer,” Archives of Medical Science, vol. 11, no. 3, pp. 561–569, 2015. View at Publisher · View at Google Scholar · View at Scopus
  50. K. Chen, J. Zeng, K. Tang et al., “miR-490-5p suppresses tumour growth in renal cell carcinoma through targeting PIK3CA,” Biology of the Cell, vol. 108, no. 2, pp. 41–50, 2016. View at Publisher · View at Google Scholar · View at Scopus
  51. K. Xu, X. Liu, X. Mao et al., “MicroRNA-149 suppresses colorectal cancer cell migration and invasion by directly targeting forkhead box transcription factor FOXM1,” Cellular Physiology and Biochemistry, vol. 35, no. 2, pp. 499–515, 2015. View at Publisher · View at Google Scholar · View at Scopus
  52. L. A. Davidson, N. Wang, M. S. Shah, J. R. Lupton, I. Ivanov, and R. S. Chapkin, “n-3 polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon,” Carcinogenesis, vol. 30, no. 12, pp. 2077–2084, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. W. P. Tsang and T. T. Kwok, “The let-7a microRNA induction of drug resistance and suppression of therapeutics-induced cell death by targeting caspase-3,” Cancer Research, vol. 13, no. 10, pp. 1215–1222, 2008. View at Google Scholar
  54. K. Yuan, K. Xie, J. Fox et al., “Decreased levels of mir-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice,” Gastroenterology, vol. 145, no. 4, pp. 853–864, 2013. View at Publisher · View at Google Scholar · View at Scopus
  55. T.-W. Ke, H.-L. Hsu, Y.-H. Wu, W. T.-L. Chen, Y.-W. Cheng, and C.-W. Cheng, “MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42,” Disease Markers, vol. 2014, Article ID 617150, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus