Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats

Figure 3

Histopathological features of the knee joint tissues of rats with MIA-induced OA. (a) Representative histological analysis (Safranin O staining) of the knee joint in MIA-induced OA. (b–d) The levels of gelatinase A (MMP-2), gelatinase B (MMP-9), and COX-2 in the femur joint were measured by ELISA. The levels of (e) DPD in urine and (f) osteocalcin in serum were measured by ELISA. indicates and indicates when compared to saline group (NC). indicates , indicates , and indicates when compared to the control group (CTL).

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