Involvement of Normalized Glial Fibrillary Acidic Protein Expression in the Hippocampi in Antidepressant-Like Effects of Xiaoyaosan on Chronically Stressed Mice

Figure 7

Effects of XYS on CUMS-induced changes in mice hippocampal astrocyte. Chronic unpredictable mild stress (CUMS) led to deficits in depressive-like behaviors in mice, which were improved by XYS administration. CUMS decreased serum BDNF and GDNF levels and reduced the protein and mRNA levels and the immunoreactivity of GFAP in the hippocampus. These abnormalities could be effectively reversed by administration of XYS. These data reveal that chronic administration of XYS elicits an antidepressant-like effect on depressive mice and may normalize the glial fibrillary acidic protein expression in the hippocampus of mice with CUMS.