Chinese Herbal Extractions for Relieving Radiation Induced Lung Injury: A Systematic Review and Meta-Analysis

Table 2

An overview of the included studies.

Study	Sample; size	Mean age (year); (median/range)	% men	Dose of radiotherapy (Gy)	CHE intervention	Control	Administration of CHE	Dose of CHE	Course of CHE (d)	Grading scale	Jadad score
Bi and Sun 2015	50	58	60.0	40–65	SFI	Placebo	iv	40 mL	42 d	RTOG	4
Cong et al. 2012	50	—	82.0	60–70	EI	—	iv	400 mg	14 d 2 cycles	RTOG	4
Duan et al. 2014	63	60.2	74.6	60–66	TRQI	—	iv	20 mL	30–33 d	RTOG	4
Duan et al. 2014	96	46.2	53.1	40–76	ADI	Glucocorticoid	iv	50 mL	20 d/40 d	RTOG	4
Gong and Luo 2009	61	61.3	62.3	—	TRQI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	20 mL	21 d	Reference	4
Hou et al. 2013	232	60	78.0	30–70	CKI	—	iv	15–20 mL	14 d 2 cycles	RTOG	4
Huang et al. 2006	62	58.7	79.0	—	SHLI + DXI	Antibiotics, Glucocorticoid	iv	60 mg + 10–20 mL	14 d	—	4
Li and Ma 2015	50	56	66.0	—	SQFZI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	250 mL	21 d	RTOG	4
Li et al. 2016	120	54.36	60.0	50–66	LI	—	iv	100 mL	35–45 d	Reference	4
Li et al. 2014	98	—	59.2	50–64	LI	—	iv	80 mg	33–42 d	RTOG	4
Liu et al. 2013	130	54	56.2	—	LBZI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	200 mg	21 d	Reference	4
Liu and Li 2016	100	65.9	53.0	64–70	LI	—	iv	120 mg	21 d	Reference	4
Liu et al. 2008	85	65	70.6	60–70	Berberine	Placebo	p.o.	20 mg/kg	42 d	RTOG	7
Pan and Tang 2006	66	46.2	53.0	40–70	SMI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	50 mL	7–14 d	RTOG	4
Ruan and Qun 2010	40	—	35.0	—	DI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	800 mg	21 d	Reference	4
Tian et al. 2006	169	32–78	58.0	—	TRQI	Antibiotics, Glucocorticoid	iv	20 mL	15 d	RTOG	4
Xu 2013	72	55.7	54.2	—	DLI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	20 mL	14 d	Reference	4
Xu 2016	68	47.1	57.4	—	XBJI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	200 mL	14 d	—	4
Xu et al. 2013	85	45	56.5	38–70	CKI	—	iv	30 mL	19–35 d	NCI-CTCAE	4
Wang et al. 2013	224	60	79.9	60–70	CKI	—	iv	15 mL	14 d	RTOG	4
Wang et al. 2016	72	66	61.1	60–66	YZXJC	—	p.o.	4.68 g	72–75 d	NCI-CTCAE	4
Yan and Jiang 2014	80	57	76.3	60–65	SMI	—	Aerosol inhalation	20 mL	35 d	RTOG	4
Yang and Jia 2010	53	59.5	60.4	40–76	SMI + Glucocorticoid	Glucocorticoid	iv	30 mL	28 d	UICC	4
Yang et al. 2015	170	61.2	60.6	56–64	TRQI	—	iv	20 mL	28 d	RTOG	4
Zhang et al. 2007	104	56.9	55.8	39–65	LBZI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	400 mg	21 d	Reference	4
Zhang et al. 2012	126	57.6	68.3	60–72	SMI	—	iv	50 mL	With radiotherapy	RTOG	4
Zheng et al. 2007	80	61.3	66.3	40–60	SQFZI + Antibiotics, Glucocorticoid	Antibiotic, Glucocorticoid	iv	250 mL	14 d	RTOG	4
Zou and Liu 2008	128	55	51.6	—	LBZI + Antibiotics, Glucocorticoid	Antibiotics, Glucocorticoid	iv	400 mg	21 d	Reference	4