Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method

Table 5

Effect of RIF and realgar (different levels) on the pharmacokinetics of caffeine ().

Parameter/unit	Control	RIF	Realgar-L	Realgar-M	Realgar-H
AUC/mg⋅L^−1⋅h	10.83 ± 1.00	15.89 ± 0.81	24.58 ± 0.22	31.01 ± 2.46	8.46 ± 0.37
AUC/mg⋅L^−1⋅h	11.80 ± 1.73	16.63 ± 1.69	26.00 ± 0.64	31.17 ± 2.60	9.36 ± 0.18
/h	6.86 ± 3.00	3.85 ± 0.41	5.09 ± 1.32	3.07 ± 0.68	7.53 ± 1.48
CL/L⋅h^−1⋅kg^−1	0.22 ± 0.03	0.15 ± 0.01	0.10 ± 0.01	0.08 ± 0.01	0.27 ± 0.01
/mg⋅L^−1	3.80 ± 0.37	6.93 ± 1.03	6.85 ± 0.26	9.01 ± 0.36	3.66 ± 0.31

versus control group.