Table 5: Effect of RIF and realgar (different levels) on the pharmacokinetics of caffeine ().

Parameter/unitControlRIFRealgar-LRealgar-MRealgar-H

AUC/mg⋅L−1⋅h10.83 ± 1.0015.89 ± 0.8124.58 ± 0.2231.01 ± 2.468.46 ± 0.37
AUC/mg⋅L−1⋅h11.80 ± 1.7316.63 ± 1.6926.00 ± 0.6431.17 ± 2.609.36 ± 0.18
/h6.86 ± 3.003.85 ± 0.415.09 ± 1.323.07 ± 0.687.53 ± 1.48
CL/L⋅h−1⋅kg−10.22 ± 0.030.15 ± 0.010.10 ± 0.010.08 ± 0.010.27 ± 0.01
/mg⋅L−13.80 ± 0.376.93 ± 1.036.85 ± 0.269.01 ± 0.363.66 ± 0.31

versus control group.