Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method

Table 6

Effect of RIF and realgar (different levels) on the pharmacokinetics of chlorzoxazone ().

Parameter/unit	Control	RIF	Realgar-L	Realgar-M	Realgar-H
AUC/mg⋅L^−1⋅h	60.88 ± 3.83	59.54 ± 1.79	61.80 ± 1.48	86.49 ± 6.03	47.96 ± 0.74
AUC/mg⋅L^−1⋅h	60.99 ± 3.78	59.97 ± 1.69	62.01 ± 1.44	89.58 ± 6.83	48.36 ± 0.98
/h	2.03 ± 1.05	3.34 ± 1.19	2.45 ± 1.16	5.76 ± 1.17	3.50 ± 1.62
CL/L⋅h^−1⋅kg^−1	0.08 ± 0.01	0.08 ± 0.01	0.08 ± 0.01	0.06 ± 0.01	0.10 ± 0.00
/mg⋅L^−1	27.33 ± 2.21	52.34 ± 6.57	37.07 ± 2.07	40.74 ± 3.61	38.78 ± 1.87

⁢ versus control group.