Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method

Table 7

Effect of RIF and realgar (different levels) on the pharmacokinetics of tolbutamide ().

Parameter/unit	Control	RIF	Realgar-L	Realgar-M	Realgar-H
AUC/mg⋅L^−1⋅h	688.30 ± 61.38	489.08 ± 23.12	696.78 ± 34.11	490.21 ± 24.92	537.08 ± 30.88
AUC/mg⋅L^−1⋅h	1016.61 ± 227.80	605.73 ± 27.78	870.12 ± 42.54	740.39 ± 161.75	629.69 ± 42.00
/h	15.43 ± 6.39	9.63 ± 1.96	10.48 ± 1.25	15.57 ± 6.49	8.88 ± 1.59
CL/L⋅h^−1⋅kg^−1	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.00	0.01 ± 0.00	0.01 ± 0.00
/mg⋅L^−1	65.01 ± 4.44	68.31 ± 4.52	79.74 ± 3.95	74.32 ± 6.99	81.07 ± 4.70

⁢ versus control group, versus control group.