Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method

Table 8

Effect of RIF and realgar (different levels) on the pharmacokinetics of midazolam ().

Parameter/unit	Control	RIF	Realgar-L	Realgar-M	Realgar-H
AUC/mg⋅L^−1⋅h	8.92 ± 1.23	9.04 ± 0.87	6.33 ± 0.14	9.26 ± 0.54	15.73 ± 1.36
AUC/mg⋅L^−1⋅h	31.38 ± 16.31	32.13 ± 16.99	22.05 ± 11.90	32.63 ± 17.46	37.50 ± 50.09
/h	4.48 ± 1.57	4.39 ± 1.87	4.40 ± 1.20	4.81 ± 1.38	6.29 ± 1.92
CL/L⋅h^−1⋅kg^−1	0.22 ± 0.16	0.23 ± 0.18	0.33 ± 0.25	0.22 ± 0.18	0.25 ± 0.10
/mg⋅L^−1	4.08 ± 0.52	5.17 ± 0.90	4.44 ± 0.17	6.56 ± 0.38	7.10 ± 0.29

⁢ versus control group, versus control group.