Kidney-Replenishing Herb Induces SOCS-3 Expression via ERK/MAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells

Figure 9

10% Kidney-replenishing herb-induced ERK1/2 phosphorylation was not affected by SOCS-3 interference in JAR cells. JAR cells were starved for 24 h, subjected to 10% Kidney-replenishing herb treatments for 8 h. The phosphorylation of ERK1/2 was observed in response to vehicle control (a) and 10% control serum (b), the protein levels of pERK1/2 was significantly increased after treatment with 10% Kidney-replenishing herb (c). The samples were controlled by immunoblot against ERK (d) and GAPDH (e).

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