Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of Acanthospermum hispidum DC. on Ovariectomized Rats with Renovascular Hypertension

Figure 2

Prolonged administration of ESAH obtained from A. hispidum reduces SBP (a), DBP (b), MAP (c), and HR (d) in 2K1C plus OVT-rats. Vehicle, ESAH (30, 100, and 300 mg/kg), ENAL (15 mg/kg), or HCTZ (25 mg/kg) was given orally for 28 days. The letter “C+” indicates the effect measured after administration of vehicle only. The results show the mean ± SEM (-7). Statistical analyses were performed by means of one-way analysis of variance (ANOVA) followed by Dunnett’s test. when compared to 2K1C plus OVT-rats (C+). when compared to Sham-operated group. ENAL: enalapril; DBP: diastolic blood pressure; HCTZ: hydrochlorothiazide; HR: heart rate; MAP: mean arterial pressure; SBP: systolic blood pressure; Sham: placebo surgery.

(a)

(b)

(c)

(d)