Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of Acanthospermum hispidum DC. on Ovariectomized Rats with Renovascular Hypertension

Table 7

Effects of oral administration of purified aqueous extract obtained from A. hispidum DC. (ESAH) on serum Na⁺, K⁺, urea, and creatinine on 28th day of treatment.

Group	Na^+ (mmol/L)	K^+ (mmol/L)	Urea (mg/dL)	Creatinine (mg/dL)
Sham
C+
ESAH (30 mg/kg)
ESAH (100 mg/kg)
ESAH (300 mg/kg)
ENAL
HCTZ

Values are expressed as mean ± SEM of 6-7 rats in each group in comparison with the positive control (C+) or Sham-operated group using one-way ANOVA followed by Dunnett’s test. HCTZ: hydrochlorothiazide; ENAL: enalapril.