Icariin Prevents H2O2-Induced Apoptosis via the PI3K/Akt Pathway in Rat Nucleus Pulposus Intervertebral Disc Cells
Icariin have no cytotoxicity in NP cells and had a significant protective effect on NP cells exposed to H2O2 at the concentration of 200 uM and this protective effect was attenuated by the PI3K/AKT pathway inhibitor LY294002. (a) H2O2 led to obvious cell death at the concentration of 200 uM to 600 uM. Results are presented as mean ± SD ( versus control group). (b) Icariin alone has no effect on the viability and proliferation of NP cells at concentrations up to 50 μM. (c) Icariin protects NP cells against H2O2-induced toxicity ( versus control group, versus H2O2 group).
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