Syndrome Differentiation of IgA Nephropathy Based on Clinicopathological Parameters: A Decision Tree Model
Table 1
Comparison of demographic and clinicopathological parameters among different TCM syndromes of training dataset.
Total ()
Qi deficiency of spleen and kidney ()
Deficiency of both qi and yin ()
Other types ()
value
Age (years)
32 (27–42)
33 (27–42)
29 (25–36)
37 (28–46)
0.025
Female, (%)
196 (53.0)
139 (50.9)
42 (63.6)
15 (48.4)
0.154
Disease course (months)
6 (2–23)
5 (1–23)
12 (3–25)
6 (2–13)
0.186
Inducement, (%)
Infection
41 (11.1)
31 (11.4)
5 (7.6)
5 (16.1)
0.780
Fatigue
13 (3.5)
11 (4.0)
1 (1.5)
1 (3.2)
Pregnancy
25 (6.8)
19 (7.0)
5 (7.6)
1 (3.2)
No obvious inducement
291 (78.6)
212 (77.7)
55 (83.3)
24 (77.4)
Systolic BP (mmHg)
120 (110–132)
120 (110–132)
120 (108–130)
125 (118–146)
0.070
Diastolic BP (mmHg)
80 (70–86)
80 (70–89)
79 (70–80)
80 (72–100)
0.097
MAP (mmHg)
93 (86–101)
93 (86–101)
91 (82–97)
94 (88–113)
0.069
Hypertension, (%)
136 (36.8)
101 (37.0)
18 (27.3)
17 (54.8)
0.031
Macroscopic hematuria, (%)
66 (17.8)
39 (14.3)
17 (25.8)
10 (32.3)
0.008
U-RBC (/μL)
45 (15–136)
32 (11–134)
60 (30–110)
74 (25–179)
0.015
Hemoglobin (g/L)
128.2 ± 20.1
129.5 ± 20.2
126.1 ± 16.2
121.1 ± 25.2
0.055
Proteinuria (g/day)
1.0 (0.5–2.2)
1.0 (0.5–2.1)
1.1 (0.5–2.5)
1.1 (0.5–2.7)
0.766
Uric acid (μmol/L)
340 (274–429)
344 (277–433)
316 (255–408)
358 (302–460)
0.170
Serum albumin (g/L)
40.3 (35.8–43.8)
40.6 (36.1–44.0)
40.2 (36.4–42.8)
39.2 (34.2–42.1)
0.405
Serum creatinine (μmol/L)
79 (59–108)
80 (61–107)
67 (56–88)
123 (63–183)
0.001
eGFR (mL/min/1.73 m2)
97.2 (67.2–120.5)
97.1 (66.3–119.9)
115.3 (82.0–125.7)
70.6 (27.7–114.2)
<0.001
eGFR (mL/min/1.73 m2)
<15
6 (1.6)
3 (1.1)
0
3 (9.7)
0.001
>15, ≤30
15 (4.1)
9 (3.3)
1 (1.5)
5 (16.1)
>30, ≤60
53 (14.3)
44 (16.1)
4 (6.1)
5 (16.1)
>60, ≤90
94 (25.4)
67 (24.5)
19 (28.8)
8 (25.8)
>90
202 (54.6)
150 (54.9)
42 (63.6)
10 (32.3)
Serum IgA (g/L)
2.85 (2.25–3.58)
2.84 (2.28–3.58)
2.81 (2.19–3.39)
2.97 (2.51–4.02)
0.246
Serum C3 (mg/L)
0.98 (0.87–1.11)
0.98 (0.87–1.12)
0.98 (0.85–1.10)
0.96 (0.85–1.08)
0.611
Oxford MEST scores
M1, (%)
361 (97.6)
269 (98.5)
64 (97.0)
28 (90.3)
0.032
E1, (%)
54 (14.6)
41 (15.0)
11 (16.7)
2 (6.5)
0.384
S1, (%)
185 (50.0)
142 (52.0)
32 (48.5)
11 (35.5)
0.210
T1, (%)
193 (52.2)
146 (53.5)
30 (45.5)
17 (54.8)
0.242
T2, (%)
68 (18.4)
48 (17.6)
12 (18.2)
8 (25.8)
BP, blood pressure; MAP, mean arterial pressure; U-RBC, urinary red blood cell; eGFR, estimated glomerular filtration rate; QDSK, qi deficiency of spleen and kidney; DBQY, deficiency of both qi and yin; OTs, other types. , , and . , , and ; . , , and ; . , , and . , , and . , , and . , , and . , , and ; .
