Research Article
Syndrome Differentiation of IgA Nephropathy Based on Clinicopathological Parameters: A Decision Tree Model
Table 4
Comparison of demographic and clinicopathological parameters among different TCM syndromes of validation dataset.
| | | Total () | Qi deficiency of spleen and kidney () | Deficiency of both qi and yin () | value |
| | Age (years) | 31 (25–42) | 33 (27–42) | 27 (22–34) | 0.015 | | Female, (%) | 47 (50.0) | 40 (50.0) | 7 (50.0) | 0.999 | | Disease course (months) | 9 (1–21) | 12 (2–24) | 1.5 (1–7.5) | 0.018 | | Inducement, (%) | | | Infection | 16 (17.0) | 12 (15.0) | 4 (28.6) | 0.327 | | Fatigue | 3 (3.2) | 2 (2.5) | 1 (7.1) | | Pregnancy | 1 (1.1) | 1 (1.2) | 0 | | No obvious inducement | 74 (78.7) | 65 (81.2) | 9 (64.3) | | Systolic BP (mmHg) | 127 (117–143) | 129 (117–143) | 122 (116–132) | 0.183 | | Diastolic BP (mmHg) | 84 (75–93) | 85 (76–94) | 81 (72–85) | 0.056 | | MAP (mmHg) | 98 (90–107) | 100 (91–110) | 93 (87–99) | 0.079 | | Hypertension, (%) | 39 (41.5) | 36 (45.0) | 3 (21.4) | 0.099 | | Macroscopic hematuria, (%) | 9 (9.6) | 8 (10.0) | 1 (7.1) | 0.999 | | U-RBC (/μL) | 40 (13–172) | 41 (18–172) | 23 (3–122) | 0.128 | | Hemoglobin (g/L) | 128.2 ± 20.1 | 124.7 ± 21.4 | 141.9 ± 21.2 | 0.006 | | Proteinuria (g/day) | 1.0 (0.5–2.4) | 1.0 (0.5–2.4) | 0.8 (0.4–1.8) | 0.644 | | Uric acid (μmol/L) | 410 (328–519) | 410 (335–521) | 400 (306–489) | 0.425 | | Serum albumin (g/L) | 39.4 (35.3–42.9) | 38.6 (34.5–42.2) | 42.9 (36.9–45.2) | 0.061 | | Serum creatinine (μmol/L) | 96 (72–151) | 104 (78–154) | 72 (64–95) | 0.012 | | eGFR (mL/min/1.73 m2) | 78.8 (50.5–109.3) | 73.3 (46.6–95.8) | 109.8 (90.8–123.8) | 0.002 | | eGFR (mL/min/1.73 m2) | | | <15 | 5 (5.3) | 5 (6.2) | 0 | 0.006 | | >15, ≤30 | 9 (9.6) | 8 (10.0) | 1 (7.1) | | >30, ≤60 | 20 (21.3) | 19 (23.8) | 1 (7.1) | | >60, ≤90 | 22 (23.4) | 21 (26.2) | 1 (7.1) | | >90 | 38 (40.4) | 27 (33.8) | 11 (78.6) | | Serum IgA (g/L) | 2.99 (2.23–3.57) | 2.98 (2.22–3.62) | 2.99 (2.23–3.45) | 0.866 | | Serum C3 (mg/L) | 1.05 (0.87–1.20) | 1.04 (0.85–1.16) | 1.20 (1.08–1.26) | 0.005 | | Oxford MEST scores | | | M1, (%) | 79 (86.8) | 69 (89.6) | 10 (71.4) | 0.085 | | E1, (%) | 11 (12.1) | 10 (13.0) | 1 (7.1) | 0.690 | | S1, (%) | 55 (60.4) | 48 (62.3) | 7 (50.0) | 0.554 | | T1, (%) | 23 (25.3) | 22 (28.6) | 1 (7.1) | 0.133 | | T2, (%) | 16 (17.6) | 14 (18.2) | 2 (14.3) |
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BP, blood pressure; MAP, mean arterial pressure; U-RBC, urinary red blood cell; eGFR, estimated glomerular filtration rate.
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