Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation

Table 2

Effects of aqueous extract of leaves from Tabebuia roseoalba (AEL), caffeic and chlorogenic acids on inhibition of xanthine oxidase activity in liver mice.

Treatment	Dose (mg/kg)	XOD activity (/mg protein)	Inhibition (%)
Hyperuricemic control	—	15.82 ± 1.63	—
Allopurinol	10	3.83 ± 0.48	76
AEL	125	11.27 ± 2.61	29
	250	10.56 ± 2.97	33
	500	8.40 ± 2.70	46
Caffeic acid	10	11.28 ± 1.06	29
	15	8.58 ± 0.79	46
Chlorogenic acid	10	10.57 ± 0.71	33
	15	10.77 ± 1.12	32

Values were expressed as mean ± SEM of six animals. For statistical significance, one-way ANOVA was used followed by Student’s Newman-Keuls test. < 0.01 and < 0.001, compared with hyperuricemic control group. = nanomole uric acid/min.