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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 2787308, 8 pages
Research Article

Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale Leaf Extract

1Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, RN, Brazil
2Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
3Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
4Department of Morphology, Federal University of Rio Grande do Norte, Natal, RN, Brazil
5Department of Food Engineering, Federal University of Campina Grande, Campina Grande, PB, Brazil

Correspondence should be addressed to Natália Cabral Souza; moc.liamtoh@micomacailatan

Received 14 April 2017; Revised 7 July 2017; Accepted 16 July 2017; Published 17 August 2017

Academic Editor: Olumayokun A. Olajide

Copyright © 2017 Natália Cabral Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In tropical America, principally in Northeastern Brazil, the leaf extract of Anacardium occidentale is traditionally used for treatment of different diseases. However, chemical and biological properties and activities of Anacardium occidentale are poorly investigated and known. Here, we evaluated the antioxidant and anti-inflammatory activities “in vitro” of leaf extract from Anacardium occidentale. Our results show that leaf extract exhibits antioxidant activity when used to treat RAW 264.7 macrophage cells. Antioxidant effects were observed by decrease in oxidative damage in macrophage cells treated with 0.5 µg/mL and 5 µg/mL of leaf extract. Moreover, leaf extract reversed oxidative damage and inflammatory parameters induced in LPS-stimulated RAW 264.7 macrophage cells. Leaf extract at 0.5 µg/mL and 5 µg/mL was able to inhibit release of TNF-α and IL-1β in LPS-stimulated cells. Taken together, our results indicate antioxidant and anti-inflammatory effects of leaf extract from Anacardium occidentale and reveal the positive effects that intake of these products can mediate in biological system.