Comparative Pharmacokinetics and Bioavailability of Three Ephedrines in Rat after Oral Administration of Unprocessed and Honey-Fried Ephedra Extract by Response Surface Experimental Design

Table 3

Precision, accuracy, recovery, and matrix effect for analyses of EH, PEH, and MEH in rat plasma.

	Concentration; (ng/mL)	Intraday; RSD (%)	Interday; RSD (%)	Accuracy; RE (%)	Recovery (%)	Matrix effect (%)
EH	20	4.7	8.4	2.9	77.8 ± 4.6	89.3 ± 2.9
	256	3.0	3.4	−5.6	82.0 ± 4.8	96.6 ± 1.7
	2560	6.7	10.9	−4.6	79.3 ± 1.4	104.0 ± 2.0
PEH	30	6.1	11.5	−4.1	83.4 ± 5.0	87.8 ± 4.1
	240	5.2	9.3	2.0	85.9 ± 3.7	102.1 ± 4.9
	2400	7.3	8.4	−4.4	81.9 ± 2.4	90.7 ± 3.1
MEH	15	9.6	6.8	9.6	79.6 ± 4.7	97.6 ± 4.8
	60	6.7	10.4	−4.1	85.3 ± 3.8	88.4 ± 5.1
	240	9.8	7.4	6.7	88.3 ± 3.1	94.0 ± 5.3