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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 2813437, 8 pages
Research Article

Role of Acupoint Area Collagen Fibers in Anti-Inflammation of Acupuncture Lifting and Thrusting Manipulation

1School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China
3Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Correspondence should be addressed to Gui-rong Dong

Received 14 December 2016; Revised 22 January 2017; Accepted 12 February 2017; Published 4 April 2017

Academic Editor: Morry Silberstein

Copyright © 2017 Fan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The role of the acupoint area collagen fibers in the efficacy of acupuncture lifting and thrusting (L&T) manipulation will be explored in this paper. 30 male NZW rabbits were randomly divided into 6 groups: sham operation group (Group N), model group (Group M), acupuncture without manipulation group (Group W), acupuncture L&T manipulation group (Group A), collagenase pretreatment group (Group JM), and collagenase pretreatment + acupuncture L&T manipulation group (Group JA). The bacterial endotoxin was used to generate the rabbit fever models. Acupuncture was applied at IL-11. The levels of IL-1β, TNF-α, and IL-4 and the rectal temperature were measured at 2 h, 4 h, and 6 h after modeling and the collagen fiber morphology at acupoint area was observed after 6 hours. Results. As compared with Group N, the levels of IL-1β and TNF-α in Group M were significantly higher; the level of IL-4 was significantly lower (). As compared with Group M, IL-1β and TNF-α in Groups W and A were significantly lower and IL-4 was significantly higher (). As compared with Group W, IL-1β and TNF-α in Group A were lower and IL-4 was higher (). The collagen fiber in Group A was slightly rough, distorted, and fractured. As shown in studies, the endotoxin-induced inflammatory response can be significantly inhibited by acupuncture whose efficacy can also be significantly improved by the manipulations. Collagenase pretreatment may be the first receptor to the mechanical force of the L&T manipulation.