Research Article
Hypericum perforatum: Synthesis of Active Principles during Flowering and Fruitification—Novel Aspects of Biological Potential
Table 2
Biological potential of the examined extract HP: antioxidant potential, inhibition of biologically important enzymes, and cytotoxic potential.
| (a) Antioxidant potential |
|
| Radical scavenging capacity (RSC) | LP | FRAP | | DPPH• | OH• | NO• |
| | RSC50 (µg/mL) | HP | | | | | | | BHT | / | | / | | / | | Ascorbic acid | / | | / | / | / | | QDH | | / | / | / | / | | PG | | | | / | / |
|
|
| (b) Inhibition of biologically important enzymes |
|
| MAO-A | MAO-B | AChE | α-Amylase | α-Glucosidase | | % of inhibition |
| | Conc. (µg/mL) | 4.09 | 73.53 | 475 | 800 | 400 | 800 | 8.32 | 16.64 |
| | | HP | | | | | | | | |
| | IC50 (µg/mL) | Moclobemide | | / | / | / | / | | Selegiline | / | | / | / | / | | Galantamine | / | / | | / | / | | Acarbose | / | / | / | | |
|
|
| (c) Cytotoxic potential |
|
| MRC-5 | HeLa | Hs-294 T | HT-29 | HeLa | Hs-294 T | HT-29 | | EC50 (µg/mL) | NT/T |
| | HP | | | | | 1.40 | 1.02 | 1.40 | | HP + BLM | | | | | 108.04 | 53.60 | 0.65 | | BLM | | | | | 1.04 | 1.77 | 0.48 |
|
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Note. NT/T: nontumor/tumor cells EC50 ratio.
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