Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats

Table 3

KEGG pathways related to sex hormones and lipolysis, significantly enriched (adjusted -value of ≤0.05) by predicted targets of Coicis Semen.

Rank	KEGG pathway	Adjusted-; value	Genes (targets)
5/63	hsa04923: Regulation of lipolysis; in adipocytes		Beta-1 adrenergic receptor; beta-2 adrenergic receptor; prostaglandin G/H synthase 2; mRNA of PKA catalytic subunit C-alpha; prostaglandin G/H synthase 1
39/63	hsa04914: Progesterone-mediated; oocyte maturation		Cell division protein kinase 2; progesterone receptor; mRNA of PKA catalytic subunit C-alpha
40/63	hsa04915: Estrogen signaling pathway		Nitric oxide synthase; mRNA of PKA catalytic subunit C-alpha; estrogen receptor
48/63	hsa04921: Oxytocin signaling pathway		Nitric oxide synthase; mRNA of PKA catalytic subunit C-alpha; prostaglandin G/H synthase 2