Table 4: KEGG pathways related to sex hormones and lipolysis, significantly enriched (adjusted -value of ≤0.05) by predicted targets of Artemisia capillaris.

RankKEGG pathwayAdjusted-
value
Genes (targets)

6/153hsa04915:
Estrogen signaling pathway
Heat shock protein HSP 90; transcription factor AP-1; nitric oxide synthase; 72 kDa type IV collagenase; mitogen-activated protein kinase 1; Mu-type opioid receptor; calmodulin; mRNA of PKA catalytic subunit C-alpha; estrogen receptor; epidermal growth factor receptor; estrogen receptor beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

17/153hsa04914:
Progesterone-mediated
oocyte maturation
Cyclin-A2; cell division control protein 2 homolog; cell division protein kinase 2; heat shock protein HSP 90; mitogen-activated protein kinase 1; mitogen-activated protein kinase 14; progesterone receptor; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform; mRNA of PKA catalytic subunit C-alpha

28/153hsa04923:
Regulation of lipolysis
in adipocytes
Insulin receptor; prostaglandin E2 receptor EP3 subtype; beta-2 adrenergic receptor; prostaglandin G/H synthase 2; mRNA of PKA catalytic subunit C-alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform; prostaglandin G/H synthase 1

57/153hsa04912:
GnRH signaling pathway
transcription factor AP-1; 72 kDa type IV collagenase; mitogen-activated protein kinase 1; mitogen-activated protein kinase 14; calmodulin mRNA of PKA catalytic subunit C-alpha; epidermal growth factor receptor

70/153hsa04921:
Oxytocin signaling pathway
Transcription factor AP-1; nitric oxide synthase; mitogen-activated protein kinase 1; calmodulin; mRNA of PKA catalytic subunit C-alpha; prostaglandin G/H synthase 2; epidermal growth factor receptor; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform