Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats

Table 4

KEGG pathways related to sex hormones and lipolysis, significantly enriched (adjusted -value of ≤0.05) by predicted targets of Artemisia capillaris.

Rank	KEGG pathway	Adjusted-; value	Genes (targets)
6/153	hsa04915: Estrogen signaling pathway		Heat shock protein HSP 90; transcription factor AP-1; nitric oxide synthase; 72 kDa type IV collagenase; mitogen-activated protein kinase 1; Mu-type opioid receptor; calmodulin; mRNA of PKA catalytic subunit C-alpha; estrogen receptor; epidermal growth factor receptor; estrogen receptor beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform
17/153	hsa04914: Progesterone-mediated; oocyte maturation		Cyclin-A2; cell division control protein 2 homolog; cell division protein kinase 2; heat shock protein HSP 90; mitogen-activated protein kinase 1; mitogen-activated protein kinase 14; progesterone receptor; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform; mRNA of PKA catalytic subunit C-alpha
28/153	hsa04923: Regulation of lipolysis; in adipocytes		Insulin receptor; prostaglandin E2 receptor EP3 subtype; beta-2 adrenergic receptor; prostaglandin G/H synthase 2; mRNA of PKA catalytic subunit C-alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform; prostaglandin G/H synthase 1
57/153	hsa04912: GnRH signaling pathway		transcription factor AP-1; 72 kDa type IV collagenase; mitogen-activated protein kinase 1; mitogen-activated protein kinase 14; calmodulin mRNA of PKA catalytic subunit C-alpha; epidermal growth factor receptor
70/153	hsa04921: Oxytocin signaling pathway		Transcription factor AP-1; nitric oxide synthase; mitogen-activated protein kinase 1; calmodulin; mRNA of PKA catalytic subunit C-alpha; prostaglandin G/H synthase 2; epidermal growth factor receptor; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform