Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation

Table 4

Effects of formulations on formalin-induced paw licking in mice.

Treatment	Licking of the hind paw (s)
	Early phase; (0–5 min)	%; Inhibition	Late phase; (15–30 min)	%; Inhibition
Compressed air	72.0 ± 10.0	—	172.80 ± 6.5	—
Vehicle	65.40 ± 8.4	—	156.60 ± 10.5	—
Formulation A	59.40 ± 5.2	9.17	134.20 ± 21.2	14.3
Formulation B	41.30 ± 4.3	36.9	159.30 ± 37.0	0.0
Formulation C	48.80 ± 4.3	25.4	146.70 ± 36.2	6.3
Formulation D	57.40 ± 9.3	12.2	97.20 ± 6.6	37.9
Formulation E	34.80 ± 3.8	46.8	62.40 ± 8.3	60.2

Each value is presented as the mean ± SEM ; indicates compared with vehicle group (Bonferroni’s test).