Dahuang Zexie Decoction Protects against High-Fat Diet-Induced NAFLD by Modulating Gut Microbiota-Mediated Toll-Like Receptor 4 Signaling Activation and Loss of Intestinal Barrier

Figure 1

Therapeutic effects of DZD on rat model of HFD-induced NAFLD. Male SD rats (8 weeks old) were fed HFD for 16 weeks, followed by either 4-week DZD feeding or normal saline supplementation through gavage, while the rats fed normal diet were set as controls. The rats were sacrificed, from which the liver and serum were collected. Body weight (a), liver weight (b), serum ALT (c), serum AST (d), serum TG (e), serum TC (f), serum HDL-C (g), serum LDL-C (h), and serum GLU (i) levels were detected. Liver sections were stained with HE (j). The data are expressed as mean ± SEM. to 8 for every group. ; . ALT: alanine aminotransferase; AST: aspartate transaminase; TG: triglyceride; TC: total cholesterol; HDL-C: high density lipoprotein-cholesterol; LDL-C: low density lipoprotein-cholesterol; GLU: glucose; HE: hematoxylin/eosin.

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