Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3β/β-Catenin Signaling Pathway

Figure 1

CWP can inhibit the proliferation of gastric cancer cell SGC-7901. (a) SGC-7901 cells in logarithmic growth phase were treated with different dosages of CWP for 12 h, 24 h, and 48 h, respectively. The inhibition of each group of cells was detected with MTT assay. (b) CWP inhibited the growth of implanted tumor; tumor volumes of each group were recorded every other day. (c) After 11 days of administration, the transplanted tumors were stripped and the volume of each tumor was measured. (d) Nude mice were subcutaneously implanted with 5 × 10⁶ SGC-7901 cells. The mice were divided into control group, CWP 1 g/ml, CWP 2 g/ml, and CWP 4 g/ml after tumor had been completely developed. (e) The tumors of each group were peeled out after 11 days. Data are expressed as the mean ± SD of 5 mice ( < 0.05 compared with control group; < 0.01 compared with control group).

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