Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3β/β-Catenin Signaling Pathway

Figure 4

CWP inhibits PI3K/AKT/GSK3β/β-catenin signaling pathway. (a) Extracts from transplanted tumor of different groups were analyzed for the expression of PI3K, p-AKT, AKT, p-GSK3β, GSK3β, β-catenin, and nuclear β-catenin. (b) Extracts from SGC-7901 cells of different groups were analyzed for the expression of PI3K, p-AKT, AKT, p-GSK3β, GSK3β, β-catenin, and nuclear β-catenin. (c) The histogram shows the relative expression of each protein in (a). (d) The histogram shows the relative expression of each protein in (b). (e) Histogram indicates the ratio of p-AKT/AKT and p-GSK3β/GSK3β of (a). (f) The histogram indicates the ratio of p-AKT/AKT and p-GSK3β/GSK3β of (b). Data are expressed as the mean ± SD of three experiments ( < 0.05 compared with control group; < 0.01 compared with control group).

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