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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 3217395, 7 pages
https://doi.org/10.1155/2017/3217395
Research Article

Prevention of AMI Induced Ventricular Remodeling: Inhibitory Effects of Heart-Protecting Musk Pill on IL-6 and TNF-Alpha

1Nanjing University of Chinese Medicine, Nanjing 210023, China
2The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210001, China
3Ganzheitliches Gesundheits Zentrum, 34305 Hessen, Germany

Correspondence should be addressed to Ning Gu

Received 13 October 2016; Revised 29 December 2016; Accepted 4 January 2017; Published 6 March 2017

Academic Editor: Ki-Wan Oh

Copyright © 2017 Wei Cen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Heart-Protecting Musk Pill (HMP) is a Traditional Chinese Medicine (TCM) that has been used for the prevention and treatment of coronary heart disease in clinic. The current study investigated the effect of HMP on the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and observed the relationship between level changes of inflammatory cytokines and ventricular remodeling in rats with acute myocardial infarction (AMI). Animal models of AMI were made by coronary artery ligation in Sprague-Dawley (SD) rats. AMI rats showed increased levels of IL-6 and TNF-α. Treatment with HMP decreases IL-6 and TNF-α concentrations in rats with AMI. Histopathological and transmission electron microscopic findings were also essentially in agreement with biochemical findings. The results of our study revealed that inflammatory cytokines IL-6 and TNF-α induce cardiac remodeling in rats after AMI; HMP improves cardiac function and ameliorates ventricular remodeling by downregulating the expression of IL-6 and TNF-α and further suppressing the ultrastructural changes of myocardial cells.