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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 3272649, 9 pages
https://doi.org/10.1155/2017/3272649
Research Article

Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells

Beijing University of Chinese Medicine, Beijing 100029, China

Correspondence should be addressed to Min Liu; nc.ude.mcub@380996 and Qingguo Wang; moc.anis@8558gqgnaw

Received 3 July 2017; Revised 4 October 2017; Accepted 9 October 2017; Published 26 November 2017

Academic Editor: Juraj Majtan

Copyright © 2017 Wenting Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dendritic cells (DCs) can secrete cytokines stimulated by lipopolysaccharide (LPS), which leads to not just acute inflammatory responses but also Th1 polarization. Furtherly, chronic inflammation or autoimmune diseases could be triggered. As a classic Traditional Chinese Medicine formula, Ephedra Aconite Asarum Decoction with the main ingredients of ephedrine and hypaconitine can show effect on anti-inflammation and immunoregulation. But it remains unclear whether Ephedra Aconite Asarum Decoction controls DCs. In this study, we investigated the effects of Ephedra Aconite Asarum Decoction on LPS-induced bone marrow-derived DCs (BMDCs) in vitro. We found that Ephedra Aconite Asarum Decoction lowered surface costimulators on DCs and reduced the expression of Th1 type cytokines. Yet it is slightly beneficial for shifting to Th2. Our work reveals that the Ephedra Aconite Asarum Decoction can regulate Th1 inflammation through intervening DCs.