Comparative Efficacy and Toxicity of Different Species of Sargassum in Haizao Yuhu Decoction in PTU-Induced Goiter Rats

Figure 2

Comparison of relative thyroid weights (a), serum levels of FT3 (b), FT4 (c), TSH (d), and TRH (e). (a) Thyroid enlargement of goiter rats could be significantly suppressed by Euthyrox, HYDf, and HYDp treatment. HYDf and HYDp showed significant effect on the PTU-induced goiter rats, which were better than that of positive control Euthyrox. (b) No difference was observed on serum levels of FT3 change in different treatment groups. (c) The reduced serum levels of FT4 in goiter rats were increased in Euthyrox, HYDf, and HYDp treatment groups. (d), (e) The elevated serum levels of TSH and TRH in goiter rats were decreased by their treatment. Data are represented as the mean ± SD, and versus normal; and versus model;    versus Euthyrox.

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