Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway

Figure 4

Wogonin improved neurite outgrowth in Tet-On Aβ₄₂-GFP SH-SY5Y cells. Aβ₄₂-GFP SH-SY5Y cells at a density of 5 × 10⁴ were pretreated with 10 μM wogonin for one day, which was followed by the addition of 10 μg/mL Dox in order to induce Aβ₄₂-GFP expression for five days. The cells were treated with vehicle as a control, and cell morphology of control (a), Dox (b), and Dox with wogonin (c) was examined by Sholl analysis to quantify neurite length and complexity. The results are shown as mean ± SEM, . Scale bar: 100 μm.

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