Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway

Figure 9

Treatment with wogonin reduces amyloid plaques in the cortex and hippocampus in 3xTg-AD mice. 3xTg-AD mice were applied with vehicle/10 mg/kg wogonin (i.p. injection) every other day from the 8th to the 24th week of age. Mice were sacrificed at the 24th week of age, and paraffin-embedded brain sections were subjected to immunohistochemical staining. (a) Immunohistochemical staining of sections from 24-week-old 3xTg-AD mice was stained with Aβ (6E10) antibodies in the cortex and hippocampus. Scale bar: 100 μm.