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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 3647801, 14 pages
https://doi.org/10.1155/2017/3647801
Research Article

Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery

1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual da Paraíba, Rua Juvêncio Arruda S/N, Bairro Universitário, 58429-600 Campina Grande, PB, Brazil
2Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil
3Departamento de Bioquímica, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil
4Departamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil
5Programas de Pós-Graduação em Engenharia e Ciência dos Materiais e Ciências da Saúde, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, No. 1130, Petrópolis, 95070-560 Caxias do Sul, RS, Brazil
6Departamento de Antibióticos, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil
7Faculdade Boa Viagem, DeVry, Av. Jean Emile Favre, No. 422, Imbiribeira, 61200-060 Recife, PE, Brazil
8Laboratório de Microscopia e Microanálise, Centro de Tecnologias Estratégicas do Nordeste, Av. Prof. Luís Freire, No. 1, Cidade Universitária, 50740-540 Recife, PE, Brazil
9Núcleo de Plataformas Tecnológicas, Instituto Aggeu Magalhães, FIOCRUZ, Av. Prof. Moraes Rego S/N, Cidade Universitária, 50740-465 Recife, PE, Brazil

Correspondence should be addressed to Rafael M. Ximenes; rb.epfu@senemix.leafar

Received 18 September 2017; Revised 20 November 2017; Accepted 29 November 2017; Published 21 December 2017

Academic Editor: Rocío De la Puerta

Copyright © 2017 Mysrayn Y. F. A. Reis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span® 80/Kolliphor® EL ratio of 6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and analyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory activity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39% A, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile. The topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu microemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.