Research Article

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Figure 2

Histological examination of the ankle joints in AA rats. Hematoxylin-eosin staining in ankle joints from control rats (a) and AA rats at week 2 with a remarkable inflammation in synovia (b) and week 8 with the remarkably destruction of cartilage and bone (c) after adjuvant injection. The thickness of the synovia was markedly suppressed in AA rats treated with TJ-20 according to schedule II (d) at week 2 after adjuvant injection. S: synovia; scale bar, 200 µm.