Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats
Influence of TJ-20 on the recruitment of macrophages and helper T cells in the synovia of ankle joint in AA rats. Photographs representing ED1-positive macrophages and W3/25-positive helper T cells in the synovia of AA rats at week 2 and AA rats treated with TJ-20 according to schedule II (a), the percentages of ED1-positive macrophages (b), and W3/25-positive helper T cells (c) in AA rats (closed circle), in AA rats treated with TJ-20 according to schedule II (open squares), and in control rats (open circle) were determined by immunohistochemistry. TJ-20 administered according to schedule II significantly lowered the increase in a number of both macrophages and helper T cells. Data are the mean ± SD for 6 rats in each group. Asterisks indicate a statistically significant difference from AA rats (, ). Scale bar, 25 µm.
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