Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Figure 5

A schematic representation of the effects and the principle molecular mechanisms of TJ-20 on adjuvant arthritis. TJ-20 reduces the recruitment of macrophages and helper T cells into the synovia of ankle joint in AA rats. Consequently, TJ-20 downregulates the production of TNF-α but augments the production of IL-10, which are mainly released by macrophages; TJ-20 also regulates the balance of Th1/Th2 ratio as it suppresses a recruitment of Th1 cells in the synovia of AA rats.