Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Tab 2

Research Article

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Table 2

Effects of TJ-20 on Thl/Th2 balance in the synovia of ankle joint in AA rats.

Time AA rats AA rats treated with TJ-20
CXCR3
(Th1)
CCR4
(Th2)
CXCR3/CCR4
Th1/Th2 ratio
CXCR3
(Th1)
CCR4
(Th2)
CXCR3/CCR4
Th1/Th2 ratio

2 weeks60 ± 6.527 ± 4.32.2246.9 ± 5.229.8 ± 4.21.57
3 weeks52 ± 5.744 ± 7.21.1843.1 ± 6.144.6 ± 3.80.97
4 weeks42 ± 4.856 ± 6.70.7538 ± 3.661.6 ± 3.10.62

By use of doubled-immunofluorescence study, we have determined the percentages of CXCR3/W3/25-double-positive cells and CCR4/W3/25-double-positive cells among total W3/25-positive cells in AA rats and AA rats with TJ-20 administration from day 7 after adjuvant injection. Data are the mean ± SD for 6 rats in each group. Asterisks indicate a statistically significant difference from AA rats (, ).

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