Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 3707046, 8 pages
https://doi.org/10.1155/2017/3707046
Research Article

Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T-Cell Cytokines

Laboratory of Cell Biology and Physiology, Department of Biochemistry and Cellular Biology, Faculty of Sciences and Technology (FAST) and Institute of Applied Biomedical Sciences (ISBA), University of Abomey-Calavi, 01 BP 918 Cotonou, Benin

Correspondence should be addressed to Akadiri Yessoufou; moc.liamg@uofuossey.iridaka

Received 30 July 2017; Revised 4 November 2017; Accepted 12 November 2017; Published 28 November 2017

Academic Editor: Victor Kuete

Copyright © 2017 Rufine Fachinan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Yessoufou, J. Gbenou, O. Grissa et al., “Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation,” BMC Complementary and Alternative Medicine, vol. 13, no. 77, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Fachinan, A. Fagninou, M. P. Nekoua et al., “Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic,” BioMed Research International, vol. 2017, pp. 1–13, 2017. View at Publisher · View at Google Scholar
  3. A. Aljohi, S. Matou-Nasri, and N. Ahmed, “Antiglycation and antioxidant properties of Momordica charantia,” PLoS ONE, vol. 11, no. 8, Article ID e0159985, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Jiang, M. Ji, W. Liu et al., “Antidiabetic activities of a cucurbitane-type triterpenoid compound from Momordica charantia in alloxan-induced diabetic mice,” Molecular Medicine Reports, vol. 14, no. 5, pp. 4865–4872, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Zhang, H. Huang, C. Liaw, S. Huang, Z. Lin, and Y. Kuo, “Cucurbitane-type triterpenes and glycoside from the rattan of wild Momordica charantia and their anti-inflammatory and cytotoxic activities,” Planta Medica, vol. 81, no. S01, pp. S1–S381, 2016. View at Publisher · View at Google Scholar
  6. Y. Sun, F. Sun, J. Li et al., “Mono-PEGylation of alpha-MMC and MAP30 from Momordica charantia L.: Production, identification and anti-tumor activity,” Molecules, vol. 21, no. 11, article 1457, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Barbieri, E. Lorenzoni, and F. Stirpe, “Inhibition of protein synthesis in vitro by a lectin from Momordica charantia and by other haemagglutinins,” Biochemical Journal, vol. 182, no. 2, pp. 633–635, 1979. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Raza, I. Ahmed, and A. John, “Tissue specific expression and immunohistochemical localization of glutathione S-transferase in streptozotocin induced diabetic rats: modulation by Momordica charantia (karela) extract,” Life Sciences, vol. 74, no. 12, pp. 1503–1511, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Ahmed, M. S. Lakhani, M. Gillett, A. John, and H. Raza, “Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats,” Diabetes Research and Clinical Practice, vol. 51, no. 3, pp. 155–161, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Welihinda, E. H. Karunanayake, M. H. H. Sheriff, and K. S. A. Jayasinghe, “Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes,” Journal of Ethnopharmacology, vol. 17, no. 3, pp. 277–282, 1986. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Welihinda, G. Arvidson, E. Gylfe, B. Hellman, and E. Karlsson, “The insulin-releasing activity of the tropical plant Momordica charantia,” Acta biologica et medica Germanica, vol. 41, no. 12, pp. 1229–1240, 1982. View at Google Scholar · View at Scopus
  12. K. C. Herold, V. Vezys, Q. Sun et al., “Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin,” The Journal of Immunology, vol. 156, no. 9, pp. 3521–3527, 1996. View at Google Scholar · View at Scopus
  13. A. Rabinovitch, “Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM: therapeutic intervention by immunostimulation?” Diabetes, vol. 43, no. 5, pp. 613–621, 1994. View at Google Scholar · View at Scopus
  14. A. Müller, P. Schott-Ohly, C. Dohle, and H. Gleichmann, “Differential regulation of Th1-type and Th2-type cytokine profiles in pancreatic islets of C57BL/6 and BALB/c mice by multiple low doses of streptozotocin,” Immunobiology, vol. 205, no. 1, pp. 35–50, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. A. A. Rossini, R. M. Williams, M. C. Appel, and A. A. Like, “Complete protection from low-dose streptozotocin-induced diabetes in mice,” Nature, vol. 276, no. 5684, pp. 182–184, 1978. View at Publisher · View at Google Scholar · View at Scopus
  16. B. M. Baranovski, G. S. Freixo-Lima, E. C. Lewis, and P. Rider, “T helper subsets, peripheral plasticity, and the acute phase protein, α1-antitrypsin,” BioMed Research International, vol. 2015, Article ID 184574, 14 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Rengarajan, S. J. Szabo, and L. H. Glimcher, “Transcriptional regulation of Th1/Th2 polarization,” Trends in Immunology, vol. 21, no. 10, pp. 479–483, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. S. C. Wood, T. D. Rao, and A. B. Frey, “Multidose streptozotocin induction of diabetes in BALB/cBy mice induces a T cell proliferation defect in thymocytes which is reversible by interleukin-4,” Cellular Immunology, vol. 192, no. 1, pp. 1–12, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. R. S. Liblau, S. M. Singer, and H. O. McDevitt, “Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases,” Trends in Immunology, vol. 16, no. 1, pp. 34–38, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. N. A. Khan, A. Yessoufou, M. Kim, and A. Hichami, “N-3 fatty acids modulate Th1 and Th2 dichotomy in diabetic pregnancy and macrosomia,” Journal of Autoimmunity, vol. 26, no. 4, pp. 268–277, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Yessoufou, A. Hichami, P. Besnard, K. Moutairou, and N. A. Khan, “Peroxisome proliferator-activated receptor α deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: modulation of T cell differentiation,” Endocrinology, vol. 147, no. 9, pp. 4410–4418, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. J. H. Buckner and S. F. Ziegler, “Regulating the immune system: The induction of regulatory T cells in the periphery,” Arthritis Research & Therapy, vol. 6, no. 5, pp. 215–222, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Sun, J. Wang, E. Pefanis et al., “Transcriptomics identify CD9 as a marker of murine IL-10-competent regulatory B cells,” Cell Reports, vol. 13, no. 6, pp. 1110–1117, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Yessoufou, A. Plé, K. Moutairou, A. Hichami, and N. A. Khan, “Docosahexaenoic acid reduces suppressive and migratory functions of CD4+CD25+ regulatory T-cells,” Journal of Lipid Research, vol. 50, no. 12, pp. 2377–2388, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Ciulei, “Methodology for analysis of vegetable drugs. practical manual on the industrial utilisation of medicinal and aromatic plants,” American Journal of Plant Sciences, pp. 1–62, 1982. View at Google Scholar
  26. E. Velázquez, H. A. Tournier, P. Mordujovich De Buschiazzo, G. Saavedra, and G. R. Schinella, “Antioxidant activity of Paraguayan plant extracts,” Fitoterapia, vol. 74, no. 1-2, pp. 91–97, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Ali, A. K. A. Khan, M. I. R. Mamun et al., “Studies on hypoglycemic effects of fruit pulp, seed, and whole plant of Momordica charantia on normal and diabetic model rats,” Planta Medica, vol. 59, no. 5, pp. 408–412, 1993. View at Publisher · View at Google Scholar · View at Scopus
  28. T. K. Ukah, A. N. Cattin-Roy, W. Chen, M. M. Miller, S. Barik, and H. Zaghouani, “On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes,” The Journal of Immunology, vol. 199, no. 3, pp. 894–902, 2017. View at Publisher · View at Google Scholar
  29. J.-T. Hung, J.-H. Liao, Y.-C. Lin et al., “Immunopathogenic role of TH1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model,” Journal of Autoimmunity, vol. 25, no. 3, pp. 181–192, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. G. M. Vaitaitis, D. M. Waid, M. G. Yussman, and D. H. Wagner, “CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes,” The Journal of Immunology, vol. 152, no. 2, pp. 243–254, 2017. View at Publisher · View at Google Scholar
  31. A. Tang, C. Li, Z. Chen, and T. Li, “Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T cells and T-bet/GATA-3 expression in NOD mice,” Molecular Medicine Reports, vol. 16, no. 4, pp. 3974–3982, 2017. View at Publisher · View at Google Scholar
  32. H. Mollazadeh, A. F. Cicero, C. N. Blesso, M. Pirro, M. Majeed, and A. Sahebkar, “Immune modulation by curcumin: The role of interleukin-10,” Critical Reviews in Food Science and Nutrition, pp. 1–13, 2017. View at Publisher · View at Google Scholar
  33. S. S. Saha and M. Ghosh, “Antioxidant and anti-inflammatory effect of conjugated linolenic acid isomers against streptozotocin-induced diabetes,” British Journal of Nutrition, vol. 108, no. 6, pp. 974–983, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Carlos, F. R. C. Costa, C. A. Pereira et al., “Mitochondrial DNA activates the NLRP3 inflammasome and predisposes to type 1 diabetes in murine model,” Frontiers in Immunology, vol. 8, article no. 164, 2017. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Lgssiar, M. Hassan, P. Schott-Ohly et al., “Interleukin-11 Inhibits NF-κB and AP-1 Activation in Islets and Prevents Diabetes Induced with Streptozotocin in Mice,” Experimental Biology and Medicine, vol. 229, no. 5, pp. 425–436, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. J. A. George, G. Bashir, M. M. Qureshi et al., “Cholinergic stimulation prevents the development of autoimmune diabetes: Evidence for the modulation of Th17 effector cells via an IFNγ-dependent mechanism,” Frontiers in Immunology, vol. 7, article no. 419, 2016. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Scuderi, A. G. D’amico, C. Federico et al., “Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes,” Journal of Molecular Neuroscience, vol. 56, no. 2, pp. 431–439, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. C.-Y. Chao, P.-J. Sung, W.-H. Wang, and Y.-H. Kuo, “Anti-inflammatory effect of momordica charantia in sepsis mice,” Molecules, vol. 19, no. 8, pp. 12777–12788, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Manabe, R. Takenaka, T. Nakasa, and O. Okinaka, “Induction of anti-inflammatory responses by dietary Momordica charantia L. (bitter gourd),” Bioscience, Biotechnology, and Biochemistry, vol. 67, no. 12, pp. 2512–2517, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. P.-Y. Li, C.-C. Hsu, M.-C. Yin et al., “Protective effects of red guava on inflammation and oxidative stress in streptozotocin-induced diabetic mice,” Molecules, vol. 20, no. 12, pp. 22341–22350, 2015. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Ye, L. Li, B. Wan et al., “Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus,” Stem Cell Research & Therapy, vol. 8, no. 1, 2017. View at Publisher · View at Google Scholar
  42. J. Deiuliis, Z. Shah, N. Shah et al., “Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers,” PLoS ONE, vol. 6, no. 1, Article ID e16376, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Feuerer, L. Herrero, D. Cipolletta et al., “Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters,” Nature Medicine, vol. 15, no. 8, pp. 930–939, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Bao, Y.-G. Chen, L. Zhang et al., “Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues,” PLoS ONE, vol. 8, no. 12, Article ID e84075, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Ike, Y. Uchida, T. Nakamura, and S. Imai, “Induction of interferon-gamma (IFN-γ) and T helper 1 (Th1) immune response by bitter gourd extract,” Journal of Veterinary Medical Science, vol. 67, no. 5, pp. 521–524, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. R. C. Johnson, E. E. Houéto, G. Boni et al., “Ethnobotanical and phytochemical study of Momordica charantia Linn (Cucurbitaceae) in Cotonou Benin,” Journal of Applied Biosciences, vol. 106, no. 1, pp. 10249–10257, 2016. View at Publisher · View at Google Scholar
  47. S. B. Mada, A. Garba, H. A. Mohammed, A. Muhammad, A. Olagunju, and A. B. Muhammad, “Antimicrobial activity and phytochemical screening of aqueous and ethanol extracts of Momordica charantia L. leaves,” Journal of Medicinal Plants Research, vol. 7, no. 10, pp. 579–586, 2013. View at Google Scholar
  48. S. Morel, A. Landreau, V. H. Nguyen et al., “Preparative isolation, fast centrifugal partition chromatography purification and biological activity of cajaflavanone from Derris ferruginea stems,” Phytochemical Analysis, vol. 23, no. 2, pp. 152–158, 2012. View at Publisher · View at Google Scholar · View at Scopus