Acupuncture Stimulation at GB34 Restores MPTP-Induced Neurogenesis Impairment in the Subventricular Zone of Mice

Figure 2

Effect of acupuncture stimulation on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced dopaminergic neuronal death and behavioral dysfunction. (a) Tyrosine hydroxylase- (TH-) specific immunohistochemical staining in the substantia nigra (SN) and striatum (ST). (b) The number of TH-positive cells in the SN. (c) The optical density of TH-positive neurons in the ST. (d) The result of the pole test. Acupuncture stimulation at GB34 suppresses MPTP-induced dopaminergic neuronal death in the SN and the ST and alleviates the MPTP-induced behavioral dysfunctions. Scale bar = 200 µm. Data are shown as the mean ± standard error of the mean. < 0.05, < 0.01, and < 0.001 versus saline group, < 0.01 and < 0.001 versus the MPTP group, and < 0.05 versus HT7 group.

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