Research Article
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B
Table 1
Inhibition (IC
50 values) of recombinant human MAO-A and MAO-B by
R. alpinia extract and isolated compounds
1–
| | Samples | Monoamine oxidase-A
IC50 (µM) | Monoamine oxidase-B
IC50 (µM) | Index MAO-A/B |
| | Renealmia alpinia dichloromethane extract | | | 2.201 | | Pinostrobin, 1 | | | 0.524 | | 4′-Methyl ether sakuranetin, 2 | | >100 | — | | Sakuranetin, 3 | | | 1.246 | | Pinostrobin chalcone, 4 | | | 0.610 | | Yashabushidiol A, 5 | >100 | | — | | Desmethoxyyangonin, 6 | | | 15.040 | | Phenelzine | | | 1.566 | | Clorgyline | | — | — | | Deprenyl | — | | — |
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IC50 values computed from the dose response inhibition curves are Mean ± SD of triplicate observations. .
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