Astragaloside IV Ameliorates Airway Inflammation in an Established Murine Model of Asthma by Inhibiting the mTORC1 Signaling Pathway

Figure 1

Experimental protocol. Mice were immunized 3 times with intraperitoneal injection of a suspension containing 40 μg OVA (Grade V) and 0.05 mL alum adjuvant. One week after the immunization, mice were challenged by exposure to an aerosol of 1% OVA for 1 week, which was followed by 3 weeks of rest. Then, mice were reexposed to OVA challenge for 1 week. From days 28 to 55, mice in the treatment groups were given oral AS-IV at 10, 20, or 40.0 mg/kg; 1 mg/kg/day dexamethasone (Dex); or 4 mg/kg/day rapamycin (Rapa).